Mingyi Xie,
Associate Professor
On This Page
About Mingyi Xie
From 2005 to 2010, Dr. Xie’s Ph.D. work focused on investigating the structure and function of vertebrate telomerase, under the guidance of Dr. Julian Chen at Arizona State University. In 2010, he joined the laboratory of Dr. Joan Steitz at Yale University to study non-canonical microRNA (miRNA) biogenesis in Herpesviruses and their mammalian hosts. Dr. Xie joined the faculty at the University of Florida in September, 2016.
Accomplishments
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Exemplary Teacher Award
College of Medicine, University of Florida
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Maximize Investigator’s Research Award (R35)
National Institute of General Medical Sciences
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Pathway to Independence Award (K99/R00)
National Cancer Institute
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Fellow Award
Leukemia & Lymphoma Society
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Leslie H. Warner Postdoc Fellow
Yale Medical School
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Outstanding Graduate Research Assistant
Department of Chemistry and Biochemistry, Arizona State University
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Award for Advanced Individual in Extra-curricular Scientific and Technological Activity
School of Life Sciences, Xiamen University
Teaching Profile
Courses Taught
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BCH5413 – Mammalian Molecular Biology and Genetics
College of Medicine
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BCH4905 – Biochemistry Senior Research
College of Medicine
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GMS6001 – Fundamentals of Biomedical Sciences I
College of Medicine
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BCH7410 – Advanced Gene Regulation
College of Medicine
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BCH6415 – Advanced Molecular and Cell Biology
College of Medicine
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GMS7979 – Advanced Research
College of Medicine
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PLP7979 – Advanced Research
College of Agricultural and Life Sciences
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GMS7980 – Research for Doctoral Dissertation
College of Medicine
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BCH7412 – Epigenetics of Human Disease and Development
College of Medicine
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GMS6905 – Independent Studies in Medical Sciences
College of Medicine
Research Profile
The overarching goal of our research is to understand how non-coding RNAs and RBPs contribute to gene regulation in health and disease. At present, we are interested in understanding how mis-regulation of microRNA levels and the modification of small non-coding RNAs contribute to different types of cancer and neurodegenerative diseases. We are investigating a microRNA degradation mechanism, called target RNA directed microRNA degradation, in the context of colorectal cancer and T-cell acute lymphoblastic leukemia. On the other hand, we discovered RNA modification called N6-methyladenosine in 7SK RNA. Erasing this modification on 7SK inhibit lung cancer cell growth. It’s regulation mechanism and therapeutic potential are being examined in the context of lung cancer and Alzheimer’s disease.
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Areas of Interest
- Cancer
- Genetics
- RNA
Publications
Academic Articles
Grants
Contact Details
- Business:
- (352) 273-8171
- Business:
- mingyi.xie@ufl.edu
- Business Mailing:
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PO Box 100245
GAINESVILLE FL 32610 - Business Street:
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PO Box 100245
GAINESVILLE FL 32610