Margaret R Wallace,
Professor
Department:
Molecular Genetics & Microbiology
Business Phone:
(352) 392-3055
Business Email:
peggyw@ufl.edu
About Margaret R Wallace
Margaret “Peggy” Wallace earned her Ph.D. in Medical Genetics at Indiana University School of Medicine in 1987, followed by postdoctoral work at the University of Michigan, where she helped clone the NF1 (neurofibromatosis type 1) gene in Dr. Francis Collins’ lab in 1990. Her own molecular genetics lab was established at the University of Florida College of Medicine in 1991, first in Pediatric Genetics, and now with a primary appointment in Molecular Genetics and Microbiology. Dr. Wallace is also involved in graduate student and medical student education.
Related Links:
Teaching Profile
Courses Taught
2019-2024
GMS6224 Foundations in Precision Medicine: Medical Molecular Genetics
2013-2014,2016-2021
GMS6001 Fundamentals of Biomedical Sciences I
2008-2024
GMS6920 Genetics Journal Colloquy
2006-2007,2019-2022
BMS6003 Genetics and Health
2014-2015,2017-2022,2022
GMS6065 Fundamentals of Cancer Biology
2007,2010-2012,2012-2016,2015-2024
GMS6012 Human Genetics
2011-2019,2021-2023
GMS5905 Special Topics in Biomedical Sciences
2018
GMS7980 Research for Doctoral Dissertation
2015-2017
GMS6895 CTS Journal Club
2006,2011-2014,2014-2016,2016
GMS6015 Human Genetics II
Research Profile
The lab works on neurofibromatosis (NF) as well as other human genetics projects (Mendelian disorders and multifactorial traits). The lab focuses on finding and characterizing genes and their mutations/variants/mechanisms that contribute to health and disease, through approaches of molecular genetics/genomics, cell biology, and animal models. Besides NF, projects have focused on genetics of pain, taste, vitiligo, cardiomyopathy, and cataracts. Dr. Wallace works closely with clinicians, and recruits her own subjects as well. Approaches in the lab include mutation analysis (including exome), variant characterization to evaluate potential pathogenesis, genetic association, RNA-level analyses, and cell culture from primary tissues and cell immortalization.
Open Researcher and Contributor ID (ORCID)
0000-0002-5202-8895
Areas of Interest
- Genetics
Publications
2023
Biopsychosocial influence on shoulder pain: results from a randomized preclinical trial of exercise-induced muscle injury.
Pain.
164(2):305-315
[DOI] 10.1097/j.pain.0000000000002700.
[PMID] 35604152.
2023
Circulating Inflammatory Biomarkers Predict Pain Change Following Exercise-Induced Shoulder Injury: Findings From the Biopsychosocial Influence on Shoulder Pain Preclinical Trial.
The journal of pain.
[DOI] 10.1016/j.jpain.2023.04.001.
[PMID] 37178095.
2023
Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis.
iScience.
26(2)
[DOI] 10.1016/j.isci.2023.106096.
[PMID] 36818284.
2022
A High-Throughput Screening Platform Identifies Novel Combination Treatments for Malignant Peripheral Nerve Sheath Tumors
Molecular Cancer Therapeutics.
21(7):1246-1258
[DOI] 10.1158/1535-7163.mct-21-0947.
2022
Analysis of AVPR1A, thermal and pressure pain thresholds, and stress in sickle cell disease.
Frontiers in pain research (Lausanne, Switzerland).
3
[DOI] 10.3389/fpain.2022.1060245.
[PMID] 36688082.
2022
HUMAN STUDY COMT and DRD3 haplotype-associated pain intensity and acute care utilization in adult sickle cell disease.
Experimental biology and medicine (Maywood, N.J.).
247(17):1601-1608
[DOI] 10.1177/15353702221080716.
[PMID] 35285297.
2022
Targeted exon skipping of NF1 exon 17 as a therapeutic for neurofibromatosis type I.
Molecular therapy. Nucleic acids.
28:261-278
[DOI] 10.1016/j.omtn.2022.03.011.
[PMID] 35433111.
2021
Effects of Patient and Surgery Characteristics on Persistent Postoperative Pain: A Mediation Analysis.
The Clinical journal of pain.
37(11):803-811
[DOI] 10.1097/AJP.0000000000000979.
[PMID] 34475340.
2021
Patient and Procedural Determinants of Postoperative Pain Trajectories.
Anesthesiology.
134(3):421-434
[DOI] 10.1097/ALN.0000000000003681.
[PMID] 33449996.
2021
Predicting long-term postsurgical pain by examining the evolution of acute pain.
European journal of pain (London, England).
25(3):624-636
[DOI] 10.1002/ejp.1698.
[PMID] 33171546.
2021
Sensory and Psychological Factors Predict Exercise-Induced Shoulder Injury Responses in a High-Risk Phenotype Cohort.
The journal of pain.
22(6):669-679
[DOI] 10.1016/j.jpain.2020.12.002.
[PMID] 33400997.
2021
Slow Dynamics of Acute Postoperative Pain Intensity Time Series Determined via Wavelet Analysis Are Associated With the Risk of Severe Postoperative Day 30 Pain.
Anesthesia and analgesia.
132(5):1465-1474
[DOI] 10.1213/ANE.0000000000005385.
[PMID] 33591118.
2021
Survival and NF1 Analysis in a Cohort of Orthopedics Patients with Malignant Peripheral Nerve Sheath Tumors
Sarcoma.
2021:1-6
[DOI] 10.1155/2021/9386823.
[PMID] 34646065.
2020
Association of P2RX7 functional variants with localized aggressive periodontitis.
Journal of periodontal research.
55(1):32-40
[DOI] 10.1111/jre.12682.
[PMID] 31292966.
2020
Genetics of human malignant peripheral nerve sheath tumors.
Neuro-oncology advances.
2(Suppl 1):i50-i61
[DOI] 10.1093/noajnl/vdz049.
[PMID] 32642732.
2020
NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation.
Acta neuropathologica.
139(1):157-174
[DOI] 10.1007/s00401-019-02086-w.
[PMID] 31664505.
2020
OPRM1, OPRK1, and COMT genetic polymorphisms associated with opioid effects on experimental pain: a randomized, double-blind, placebo-controlled study.
The pharmacogenomics journal.
20(3):471-481
[DOI] 10.1038/s41397-019-0131-z.
[PMID] 31806881.
2019
Assessment of nociception and related quality-of-life measures in a porcine model of neurofibromatosis type 1.
Pain.
160(11):2473-2486
[DOI] 10.1097/j.pain.0000000000001648.
[PMID] 31246731.
2019
Associations of P2RX7 Functional Diplotypes with Localized Aggressive Periodontitis.
JDR clinical and translational research.
4(4):342-351
[DOI] 10.1177/2380084419863789.
[PMID] 31319038.
2019
EZH1/2 function mostly within canonical PRC2 and exhibit proliferation-dependent redundancy that shapes mutational signatures in cancer
Proceedings of the National Academy of Sciences.
116(13):6075-6080
[DOI] 10.1073/pnas.1814634116.
[PMID] 30867289.
2019
Low mutation burden and frequent loss of CDKN2A/B and SMARCA2, but not PRC2, define premalignant neurofibromatosis type 1-associated atypical neurofibromas.
Neuro-oncology.
21(8):981-992
[DOI] 10.1093/neuonc/noz028.
[PMID] 30722027.
2018
A porcine model of neurofibromatosis type 1 that mimics the human disease.
JCI insight.
3(12)
[DOI] 10.1172/jci.insight.120402.
[PMID] 29925695.
2018
Development of 3D culture models of plexiform neurofibroma and initial application for phenotypic characterization and drug screening.
Experimental neurology.
299(Pt B):289-298
[DOI] 10.1016/j.expneurol.2017.10.012.
[PMID] 29055717.
2018
Genetic and psychological factors interact to predict physical impairment phenotypes following exercise-induced shoulder injury
Journal of Pain Research.
Volume 11:2497-2508
[DOI] 10.2147/jpr.s171498.
2018
Genetic polymorphisms and periodontal disease in populations of African descent: A review.
Journal of periodontal research.
53(2):164-173
[DOI] 10.1111/jre.12505.
[PMID] 29105764.
2018
Genotype-Phenotype Correlation in NF1: Evidence for a More Severe Phenotype Associated with Missense Mutations Affecting NF1 Codons 844-848.
American journal of human genetics.
102(1):69-87
[DOI] 10.1016/j.ajhg.2017.12.001.
[PMID] 29290338.
2018
Neurofibromin level directs RAS pathway signaling and mediates sensitivity to targeted agents in malignant peripheral nerve sheath tumors.
Oncotarget.
9(32):22571-22585
[DOI] 10.18632/oncotarget.25181.
[PMID] 29854299.
2018
Pharmacological and genomic profiling of neurofibromatosis type 1 plexiform neurofibroma-derived schwann cells.
Scientific data.
5
[DOI] 10.1038/sdata.2018.106.
[PMID] 29893754.
2017
Biopsychosocial influence on shoulder pain: Rationale and protocol for a pre-clinical trial.
Contemporary clinical trials.
56:9-17
[DOI] 10.1016/j.cct.2017.03.005.
[PMID] 28315479.
2017
Single Nucleotide Polymorphism in the COL11A2 Gene Associated with Heat Pain Sensitivity in Knee Osteoarthritis.
Molecular pain.
13
[DOI] 10.1177/1744806917724259.
[PMID] 28741447.
2017
The primacy of NF1 loss as the driver of tumorigenesis in neurofibromatosis type 1-associated plexiform neurofibromas.
Oncogene.
36(22):3168-3177
[DOI] 10.1038/onc.2016.464.
[PMID] 28068329.
2017
Versatile and precise gene-targeting strategies for functional studies in mammalian cell lines.
Methods (San Diego, Calif.).
121-122:45-54
[DOI] 10.1016/j.ymeth.2017.05.003.
[PMID] 28499832.
2016
Biopsychosocial Influence on Shoulder Pain: Influence of Genetic and Psychological Combinations on Twelve-Month Postoperative Pain and Disability Outcomes.
Arthritis care & research.
68(11):1671-1680
[DOI] 10.1002/acr.22876.
[PMID] 26945673.
2016
Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants.
Nature genetics.
48(11):1418-1424
[DOI] 10.1038/ng.3680.
[PMID] 27723757.
2016
Immortalization of human normal and NF1 neurofibroma Schwann cells.
Laboratory investigation; a journal of technical methods and pathology.
96(10):1105-15
[DOI] 10.1038/labinvest.2016.88.
[PMID] 27617404.
2015
Biopsychosocial influence on shoulder pain: risk subgroups translated across preclinical and clinical prospective cohorts.
Pain.
156(1):148-156
[DOI] 10.1016/j.pain.0000000000000012.
[PMID] 25599310.
2014
Biopsychosocial influence on exercise-induced injury: genetic and psychological combinations are predictive of shoulder pain phenotypes.
The journal of pain.
15(1):68-80
[DOI] 10.1016/j.jpain.2013.09.012.
[PMID] 24373571.
2014
Inflammatory genes and psychological factors predict induced shoulder pain phenotype.
Medicine and science in sports and exercise.
46(10):1871-81
[DOI] 10.1249/MSS.0000000000000328.
[PMID] 24598699.
2014
Investigation of Gene X Gene Interactions in a Model of Exercise Induced Shoulder Pain
Journal of Pain.
15(4, 1)
2014
Jaffe-Campanacci syndrome, revisited: detailed clinical and molecular analyses determine whether patients have neurofibromatosis type 1, coincidental manifestations, or a distinct disorder.
Genetics in medicine : official journal of the American College of Medical Genetics.
16(6):448-59
[DOI] 10.1038/gim.2013.163.
[PMID] 24232412.
2014
Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis.
The American journal of pathology.
184(7):2082-98
[DOI] 10.1016/j.ajpath.2014.04.006.
[PMID] 24832557.
2013
Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance.
Cancer discovery.
3(6):674-89
[DOI] 10.1158/2159-8290.CD-13-0081.
[PMID] 23535903.
2013
Do polymorphisms in the TAS1R1 gene contribute to broader differences in human taste intensity?
Chemical senses.
38(8):719-28
[DOI] 10.1093/chemse/bjt040.
[PMID] 24000232.
2013
Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis.
Nature genetics.
45(7):756-66
[DOI] 10.1038/ng.2641.
[PMID] 23685747.
2012
Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.
Sarcoma.
2012
[DOI] 10.1155/2012/620834.
[PMID] 23319880.
2012
Ethnicity interacts with the OPRM1 gene in experimental pain sensitivity.
Pain.
153(8):1610-1619
[DOI] 10.1016/j.pain.2012.03.022.
[PMID] 22717102.
2012
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
Nature genetics.
44(6):676-80
[DOI] 10.1038/ng.2272.
[PMID] 22561518.
2012
Regulation of mTOR complex 2 signaling in neurofibromatosis 2-deficient target cell types.
Molecular cancer research : MCR.
10(5):649-59
[DOI] 10.1158/1541-7786.MCR-11-0425-T.
[PMID] 22426462.
2012
Variation in the gene TAS2R13 is associated with differences in alcohol consumption in patients with head and neck cancer.
Chemical senses.
37(8):737-44
[DOI] 10.1093/chemse/bjs063.
[PMID] 22824251.
2011
Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors toward common bitter beverages in adults.
Chemical senses.
36(3):311-9
[DOI] 10.1093/chemse/bjq132.
[PMID] 21163912.
2011
Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP.
The Journal of investigative dermatology.
131(2):371-81
[DOI] 10.1038/jid.2010.337.
[PMID] 21085187.
2011
Genome-wide analysis identifies a quantitative trait locus in the MHC class II region associated with generalized vitiligo age of onset.
The Journal of investigative dermatology.
131(6):1308-12
[DOI] 10.1038/jid.2011.12.
[PMID] 21326295.
2011
Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction.
Nature neuroscience.
14(12):1569-73
[DOI] 10.1038/nn.2941.
[PMID] 22019732.
2011
Two novel mutations of SCN9A (Nav1.7) are associated with partial congenital insensitivity to pain.
European journal of pain (London, England).
15(3):223-30
[DOI] 10.1016/j.ejpain.2010.07.003.
[PMID] 20692858.
2010
Analysis of steroid hormone effects on xenografted human NF1 tumor schwann cells.
Cancer biology & therapy.
10(8):758-64
[PMID] 20699653.
2010
Common variants in FOXP1 are associated with generalized vitiligo.
Nature genetics.
42(7):576-8
[DOI] 10.1038/ng.602.
[PMID] 20526340.
2010
Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin.
Clinical cancer research : an official journal of the American Association for Cancer Research.
16(20):5048-57
[DOI] 10.1158/1078-0432.CCR-10-0613.
[PMID] 20739432.
2010
HPV in head and neck cancers among 5-year survivors.
American journal of clinical oncology.
33(4):425-6
[DOI] 10.1097/COC.0b013e3181d6b43a.
[PMID] 20689367.
2010
MicroRNA-10b regulates tumorigenesis in neurofibromatosis type 1.
Cancer science.
101(9):1997-2004
[DOI] 10.1111/j.1349-7006.2010.01616.x.
[PMID] 20550523.
2010
Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.
The New England journal of medicine.
362(18):1686-97
[DOI] 10.1056/NEJMoa0908547.
[PMID] 20410501.
2009
A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene.
Blood.
113(5):1075-85
[DOI] 10.1182/blood-2008-03-144436.
[PMID] 18948576.
2009
Expansion of the human mu-opioid receptor gene architecture: novel functional variants.
Human molecular genetics.
18(6):1037-51
[DOI] 10.1093/hmg/ddn439.
[PMID] 19103668.
2009
Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene.
EMBO molecular medicine.
1(4):236-48
[DOI] 10.1002/emmm.200900027.
[PMID] 20049725.
2009
Modeling genetic imprinting effects of DNA sequences with multilocus polymorphism data.
Algorithms for molecular biology : AMB.
4
[DOI] 10.1186/1748-7188-4-11.
[PMID] 19671182.
2009
Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase.
Molecular carcinogenesis.
48(11):1005-17
[DOI] 10.1002/mc.20552.
[PMID] 19479903.
2008
A computational model for sex-specific genetic architecture of complex traits in humans: implications for mapping pain sensitivity.
Molecular pain.
4
[DOI] 10.1186/1744-8069-4-13.
[PMID] 18416828.
2008
Biopsychosocial influence on exercise-induced delayed onset muscle soreness at the shoulder: pain catastrophizing and catechol-o-methyltransferase (COMT) diplotype predict pain ratings.
The Clinical journal of pain.
24(9):793-801
[DOI] 10.1097/AJP.0b013e31817bcb65.
[PMID] 18936597.
2008
Evidence for a biopsychosocial influence on shoulder pain: pain catastrophizing and catechol-O-methyltransferase (COMT) diplotype predict clinical pain ratings.
Pain.
136(1-2):53-61
[PMID] 17686583.
2008
Genetic contributions to pain: a review of findings in humans.
Oral diseases.
14(8):673-82
[DOI] 10.1111/j.1601-0825.2008.01458.x.
[PMID] 19193196.
2008
Influence of hormones and hormone metabolites on the growth of Schwann cells derived from embryonic stem cells and on tumor cell lines expressing variable levels of neurofibromin.
Developmental dynamics : an official publication of the American Association of Anatomists.
237(2):513-24
[DOI] 10.1002/dvdy.21430.
[PMID] 18213578.
2008
Novel Tas2R Snp Associations With Taste Sensation, Liking Or Intake for Alcoholic and Bitter Non-Alcoholic Beverages
Chemical Senses.
33
2008
p53 regulates FAK expression in human tumor cells.
Molecular carcinogenesis.
47(5):373-82
[PMID] 17999388.
2007
An orthotopic xenograft model of intraneural NF1 MPNST suggests a potential association between steroid hormones and tumor cell proliferation.
Laboratory investigation; a journal of technical methods and pathology.
87(11):1092-102
[PMID] 17876295.
2007
In vitro studies of steroid hormones in neurofibromatosis 1 tumors and Schwann cells.
Molecular carcinogenesis.
46(7):512-23
[PMID] 17393410.
2007
Plexiform-like neurofibromas develop in the mouse by intraneural xenograft of an NF1 tumor-derived Schwann cell line.
Journal of neuroscience research.
85(6):1347-57
[PMID] 17335073.
2007
Variation in optineurin (OPTN) allele frequencies between and within populations.
Molecular vision.
13:151-63
[PMID] 17293779.
2006
Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.
Cancer research.
66(5):2584-91
[PMID] 16510576.
2006
Nf1 haploinsufficiency augments angiogenesis.
Oncogene.
25(16):2297-303
[PMID] 16288202.
2005
Analysis of somatic NF1 promoter methylation in plexiform neurofibromas and Schwann cells.
Cancer genetics and cytogenetics.
157(2):181-6
[PMID] 15721644.
2005
Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study.
International journal of obesity (2005).
29(7):746-54
[PMID] 15917856.
2005
Fine mapping of chromosome 17 translocation breakpoints > or = 900 Kb upstream of SOX9 in acampomelic campomelic dysplasia and a mild, familial skeletal dysplasia.
American journal of human genetics.
76(4):663-71
[PMID] 15717285.
2005
Genetic linkage of a novel autosomal dominant restrictive cardiomyopathy locus.
Journal of medical genetics.
42(8):663-5
[PMID] 16061566.
2005
Inheritance of cataract in the Bichon Frise.
Veterinary ophthalmology.
8(3):203-5
[PMID] 15910375.
2005
Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans.
Journal of medical genetics.
42(7):583-7
[PMID] 15994880.
2005
The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans.
The journal of pain.
6(3):159-67
[PMID] 15772909.
2005
Tumorigenic properties of neurofibromin-deficient Schwann cells in culture and as syngrafts in Nf1 knockout mice.
Journal of neuroscience research.
82(3):357-67
[PMID] 16180234.
2004
Blood lymphocyte chimerism associated with IVF and monochorionic dizygous twinning: case report.
Human reproduction (Oxford, England).
19(12):2816-21
[PMID] 15375077.
2003
Cataracts in the Bichon Frise.
Veterinary ophthalmology.
6(1):3-9
[PMID] 12641835.
2003
Delayed rectifier K currents in NF1 Schwann cells. Pharmacological block inhibits proliferation.
Neurobiology of disease.
13(2):136-46
[PMID] 12828937.
2003
Routine cytogenetic and FISH studies for 17p11/15q11 duplications and subtelomeric rearrangement studies in children with autism spectrum disorders.
American journal of medical genetics. Part A.
117A(2):105-11
[PMID] 12567405.
2003
The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans.
Proceedings of the National Academy of Sciences of the United States of America.
100(8):4867-72
[PMID] 12663858.
2002
RT-PCR splicing analysis of the NF1 open reading frame.
Human genetics.
110(5):495-502
[PMID] 12073021.
2002
The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.
Molecular medicine (Cambridge, Mass.).
8(1):56-64
[PMID] 11984006.
2001
Clinical and molecular studies of a large family with desmin-associated restrictive cardiomyopathy.
Clinical genetics.
59(4):248-56
[PMID] 11298680.
2001
Effects of beta1-adrenoceptor genetic polymorphisms on resting hemodynamics in patients undergoing diagnostic testing for ischemia.
The American journal of cardiology.
88(9):1034-7
[PMID] 11704005.
2001
Randomized, placebo-controlled clinical trial of oral azithromycin prophylaxis against respiratory infections in a high-risk, young adult population.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
33(7):983-9
[PMID] 11528569.
2001
Supravalvular aortic stenosis: genetic and molecular dissection of a complex mutation in the elastin gene.
Human genetics.
109(5):512-20
[PMID] 11735026.
2001
Tumorigenic properties of neurofibromin-deficient neurofibroma Schwann cells.
The American journal of pathology.
158(2):501-13
[PMID] 11159187.
2000
Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis type 1.
Genes, chromosomes & cancer.
28(4):425-31
[PMID] 10862051.
2000
Culture of cytogenetically abnormal schwann cells from benign and malignant NF1 tumors.
Genes, chromosomes & cancer.
27(2):117-23
[PMID] 10612798.
2000
Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis.
Proceedings of the National Academy of Sciences of the United States of America.
97(8):4144-9
[PMID] 10737774.
2000
Sequencing of beta 2-adrenoceptor gene PCR products using Taq BigDye terminator chemistry results in inaccurate base calling.
BioTechniques.
29(5):962-4, 966, 968 passim
[PMID] 11084855.
1999
A new hereditary cylindromatosis family associated with CYLD1 on chromosome 16.
Human genetics.
105(1-2):171-3
[PMID] 10480375.
1999
Efficacy of influenza vaccination in HIV-infected persons. A randomized, double-blind, placebo-controlled trial.
Annals of internal medicine.
131(6):430-3
[PMID] 10498559.
1999
Elastin region deletions in Williams syndrome.
Genetic testing.
3(4):357-9
[PMID] 10627943.
1999
Exon 10b of the NF1 gene represents a mutational hotspot and harbors a recurrent missense mutation Y489C associated with aberrant splicing.
Genetics in medicine : official journal of the American College of Medical Genetics.
1(6):248-53
[PMID] 11258625.
1998
Analysis of CpG C-to-T mutations in neurofibromatosis type 1. Mutations in brief no. 129. Online.
Human mutation.
11(5)
[PMID] 10336779.
1998
Constitutional and mosaic large NF1 gene deletions in neurofibromatosis type 1.
Journal of medical genetics.
35(6):468-71
[PMID] 9643287.
1998
Effects of influenza vaccination in HIV-infected adults: a double-blind, placebo-controlled trial.
Vaccine.
16(9-10):1039-42
[PMID] 9682356.
1998
Identification of two novel mutations (1448delA and Q682X) in the NF1 gene and analysis for nonsense mutations in patients with neurofibromatosis type 1.
Human mutation.
Suppl 1:S47-9
[PMID] 9452037.
1998
Newly described form of X-linked arthrogryposis maps to the long arm of the human X chromosome.
American journal of medical genetics.
78(5):450-4
[PMID] 9714012.
1998
Once weekly azithromycin therapy for prevention of Mycobacterium avium complex infection in patients with AIDS: a randomized, double-blind, placebo-controlled multicenter trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
26(3):611-9
[PMID] 9524832.
1997
Four frameshift mutations in neurofibromatosis type 1 caused by small insertions.
Journal of medical genetics.
34(7):579-81
[PMID] 9222967.
1997
Identification of mutations in two major mRNA isoforms of the Chediak-Higashi syndrome gene in human and mouse.
Human molecular genetics.
6(7):1091-8
[PMID] 9215680.
1997
NF1 mutation analysis using a combined heteroduplex/SSCP approach.
Human mutation.
9(6):548-54
[PMID] 9195229.
1997
Physical mapping of the chromosome 7 breakpoint region in an SLOS patient with t(7;20) (q32.1;q13.2).
American journal of medical genetics.
68(3):279-81
[PMID] 9024559.
1996
A multiplex-PCR test for EVI2A and EVI2B polymorphisms within the human NF1 gene.
Mammalian genome : official journal of the International Mammalian Genome Society.
7(3):233-4
[PMID] 8833251.
1996
Somatic mosaicism in a patient with neurofibromatosis type 1.
American journal of human genetics.
58(3):484-90
[PMID] 8644707.
1995
Benign neurofibromas in type 1 neurofibromatosis (NF1) show somatic deletions of the NF1 gene.
Nature genetics.
11(1):90-2
[PMID] 7550323.
1995
Identification of a yeast artificial chromosome clone spanning a translocation breakpoint at 7q32.1 in a Smith-Lemli-Opitz syndrome patient.
American journal of human genetics.
56(6):1411-6
[PMID] 7762564.
1995
Sequential emergence of multi-resistant Klebsiella pneumoniae in Bahrain.
The Journal of hospital infection.
31(4):247-52
[PMID] 8926374.
1994
A PCR-based test for a polymorphism within the human NF1 gene.
Clinical genetics.
45(6)
[PMID] 7923863.
1994
Confirmation of linkage of supravalvular aortic stenosis to the elastin gene on chromosome 7q.
The American journal of cardiology.
74(12):1281-3
[PMID] 7977109.
1994
Neurofibromatosis type 1.
European journal of cancer (Oxford, England : 1990).
30A(13):1974-81
[PMID] 7734210.
1994
Ten base pair duplication in exon 38 of the NF1 gene.
Human molecular genetics.
3(5):829-30
[PMID] 8081372.
1994
Two NF1 mutations: frameshift in the GAP-related domain, and loss of two codons toward the 3′ end of the gene.
Human mutation.
3(4):347-52
[PMID] 8081387.
1993
Characterization of a single base-pair deletion in neurofibromatosis type 1.
Human molecular genetics.
2(10):1709-11
[PMID] 8268926.
1993
Linkage mapping in familial breast cancer: improved localisation of a susceptibility locus on chromosome 17q12-21.
International journal of cancer.
53(2):188-98
[PMID] 8425756.
1993
Linkage of a major breast cancer gene to chromosome 17q12-21: results from 15 Edinburgh families.
American journal of human genetics.
52(4):723-9
[PMID] 8460638.
1992
A yeast artificial chromosome contig encompassing the type 1 neurofibromatosis gene.
Genomics.
13(3):672-80
[PMID] 1639394.
1992
NF1-related locus on chromosome 15.
Genomics.
13(4):1316-8
[PMID] 1505963.
1992
Sequencing and analysis of genomic fragments from the NF1 locus.
DNA sequence : the journal of DNA sequencing and mapping.
3(4):237-43
[PMID] 1338369.
1991
A de novo Alu insertion results in neurofibromatosis type 1.
Nature.
353(6347):864-6
[PMID] 1719426.
1991
A highly polymorphic cDNA probe in the NF1 gene.
Nucleic acids research.
19(13)
[PMID] 1677185.
1991
A polymorphic cDNA probe on chromosome 17q11.2 located within the NF1 gene [D17S376].
Nucleic acids research.
19(1)
[PMID] 1672744.
1991
cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product.
Genomics.
11(4):931-40
[PMID] 1783401.
1991
cDNA sequence and genomic structure of EV12B, a gene lying within an intron of the neurofibromatosis type 1 gene.
Genomics.
9(3):446-60
[PMID] 1903357.
1991
Molecular genetics of von Recklinghausen neurofibromatosis.
Advances in human genetics.
20:267-307
[PMID] 1801591.
1990
A 90 kb DNA deletion associated with neurofibromatosis type 1.
Journal of medical genetics.
27(12):738-41
[PMID] 2127432.
1990
A chromosome jump crosses a translocation breakpoint in the von Recklinghausen neurofibromatosis region.
Genes, chromosomes & cancer.
2(4):271-7
[PMID] 2176541.
1990
Human chromosome 17 NotI linking clones and their use in long-range restriction mapping of the Miller-Dieker chromosome region (MDCR) in 17p13.3.
Genomics.
7(2):264-9
[PMID] 2347590.
1990
Isolation of a polymorphic DNA sequence (LL101) from the short arm of chromosome 17 [D17S251].
Nucleic acids research.
18(4)
[PMID] 1969146.
1990
Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients.
Science (New York, N.Y.).
249(4965):181-6
[PMID] 2134734.
1989
Direct construction of a chromosome-specific NotI linking library from flow-sorted chromosomes.
Nucleic acids research.
17(4):1665-77
[PMID] 2784207.
1989
Physical mapping of a translocation breakpoint in neurofibromatosis.
Science (New York, N.Y.).
244(4908):1085-7
[PMID] 2543076.
1989
Physical mapping of the von Recklinghausen neurofibromatosis region on chromosome 17.
American journal of human genetics.
44(1):58-67
[PMID] 2491783.
1989
Refined physical and genetic mapping of the NF1 region on chromosome 17.
American journal of human genetics.
45(5):721-8
[PMID] 2573276.
1988
Genetic linkage map of human chromosome 21.
Genomics.
3(2):129-36
[PMID] 2906323.
1986
Studies of a DNA marker (G8) genetically linked to Huntington disease in British families.
Human genetics.
73(4):333-9
[PMID] 3017842.
1984
DNA markers for nervous system diseases.
Science (New York, N.Y.).
225(4668):1320-6
[PMID] 6089346.
1984
Huntington disease: estimation of heterozygote status using linked genetic markers.
Genetic epidemiology.
1(1):81-8
[PMID] 6242401.
1983
A polymorphic DNA marker genetically linked to Huntington’s disease.
Nature.
306(5940):234-8
[PMID] 6316146.
Data from A High-Throughput Screening Platform Identifies Novel Combination Treatments for Malignant Peripheral Nerve Sheath Tumors
.
[DOI] 10.1158/1535-7163.c.6543243.v1.
Data from A High-Throughput Screening Platform Identifies Novel Combination Treatments for Malignant Peripheral Nerve Sheath Tumors
.
[DOI] 10.1158/1535-7163.c.6543243.
Supplementary Figure from A High-Throughput Screening Platform Identifies Novel Combination Treatments for Malignant Peripheral Nerve Sheath Tumors
.
[DOI] 10.1158/1535-7163.22521984.
Supplementary Figure from A High-Throughput Screening Platform Identifies Novel Combination Treatments for Malignant Peripheral Nerve Sheath Tumors
.
[DOI] 10.1158/1535-7163.22521984.v1.
Supplementary Table from A High-Throughput Screening Platform Identifies Novel Combination Treatments for Malignant Peripheral Nerve Sheath Tumors
.
[DOI] 10.1158/1535-7163.22521981.
Supplementary Table from A High-Throughput Screening Platform Identifies Novel Combination Treatments for Malignant Peripheral Nerve Sheath Tumors
.
[DOI] 10.1158/1535-7163.22521981.v1.
Grants
Dec 2022
– May 2023
Professional Service Agreement
Role: Principal Investigator
Funding: INDIANA UNIV
Oct 2022
ACTIVE
Study of NF1 in Families
Role: Principal Investigator
Funding: CHILDRENS TUMOR FOU
Apr 2021
– Dec 2022
UFF UF Neurofibromatosis Research: Wallace Genetics Bank
Role: Principal Investigator
Funding: UF FOUNDATION
Jul 2020
– Jul 2021
Contributions of biopsychosocial factors in sickle cell disease pain
Role: Other
Funding: NATL INST OF HLTH NHLBI
May 2020
– May 2022
Analysis of Clinical and Molecular Parameters in MPNST
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Jul 2018
– Jun 2022
Genetic Studies of Neurofibromatosis
Role: Principal Investigator
Funding: JOHNS HOPKINS UNIVERSITY
via BLOOMBERG FAMILY FOU – PHILANTHROPIES
Jan 2017
ACTIVE
Distribution of Immortalized Schwann Cell Lines
Role: Principal Investigator
Funding: MULTIPLE SPONSORS
Sep 2016
– Apr 2022
BIOPSYCHOSOCIAL INFLUENCE ON SHOULDER PAIN
Role: Co-Investigator
Funding: DUKE UNIVERSITY
via NATL INST OF HLTH NIAMS
Jul 2015
– Jun 2021
Finding Good TEMporal PostOperative pain Signatures (TEMPOS)
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Jun 2015
– Jun 2018
Wallace CTF Contract
Role: Principal Investigator
Funding: CHILDRENS TUMOR FOU
Jun 2014
– Nov 2021
Mechanisms and Treatment Response of Aggressive Periodontitis in Children
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Jun 2013
– May 2016
Development of a Plexiform Neurofibroma Cellular Assay for High-Throughput Screening
Role: Principal Investigator
Funding: JOHNS HOPKINS UNIVERSITY
Jan 2008
– Oct 2020
UF Fibromatosis Research
Role: Principal Investigator
Funding: UF FOUNDATION
Sep 2002
ACTIVE
92050504
Role: Project Manager
Funding: HAYWARD FOU, JOHN & WINIFRED
Education
Ph.D., Medical Genetics
1982-1987
·
Indiana University, School of Medicine
Contact Details
Phones:
- Business:
- (352) 392-3055
Emails:
- Business:
- peggyw@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100266
GAINESVILLE FL 32610 - Business Street:
-
RG-293, RG-285 ARB
GAINESVILLE FL 32610