Lukasz J Sznajder

Lukasz J Sznajder,

Research Assistant Professor

Department: Molecular Genetics & Microbiology
Business Phone: (352) 273-8183
Business Email: ljsznajder@ufl.edu

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0001-6822-6485

Publications

2021
The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1
Nature Biomedical Engineering. [DOI] 10.1038/s41551-020-00607-7. [PMID] 32929188.
2020
Loss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood
Nature Communications. [DOI] 10.1038/s41467-020-15962-x. [PMID] 32332745.
2019
Cell-type-specific dysregulation of RNA alternative splicing in short tandem repeat mouse knockin models of myotonic dystrophy.
Genes & development. [DOI] 10.1101/gad.328963.119. [PMID] 31624084.
2019
Short Tandem Repeat Expansions and RNA-Mediated Pathogenesis in Myotonic Dystrophy
International Journal of Molecular Sciences. [DOI] 10.3390/ijms20133365. [PMID] 31323950.
2018
Intron retention induced by microsatellite expansions as a disease biomarker
Proceedings of the National Academy of Sciences. [DOI] 10.1073/pnas.1716617115. [PMID] 29610297.
2018
MBNL splicing activity depends on RNA binding site structural context
Nucleic Acids Research. [DOI] 10.1093/nar/gky565. [PMID] 29955876.
2018
Myotonic Dystrophy and Developmental Regulation of RNA Processing.
Comprehensive Physiology. [DOI] 10.1002/cphy.c170002. [PMID] 29687899.
2017
Autoregulation of MBNL1 function by exon 1 exclusion from MBNL1 transcript.
Nucleic acids research. [DOI] 10.1093/nar/gkw1158. [PMID] 27903900.
2017
Disrupted prenatal RNA processing and myogenesis in congenital myotonic dystrophy.
Genes & development. [DOI] 10.1101/gad.300590.117. [PMID] 28698297.
2017
Hybrid splicing minigene and antisense oligonucleotides as efficient tools to determine functional protein/RNA interactions.
Scientific reports. [DOI] 10.1038/s41598-017-17816-x. [PMID] 29242583.
2016
Mechanistic determinants of MBNL activity.
Nucleic acids research. [PMID] 27733504.
2015
Short antisense-locked nucleic acids (all-LNAs) correct alternative splicing abnormalities in myotonic dystrophy.
Nucleic acids research. [DOI] 10.1093/nar/gkv163. [PMID] 25753670.
2012
Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts.
ACS chemical biology. [DOI] 10.1021/cb200413a. [PMID] 22252896.
2011
Northern blotting analysis of microRNAs, their precursors and RNA interference triggers.
BMC molecular biology. [DOI] 10.1186/1471-2199-12-14. [PMID] 21481235.

Grants

Feb 2018 – Jan 2021
Pre-mRNA Misprocessing in Myotonic Dystrophy and Amyotrophic Lateral Sclerosis
Role: Principal Investigator
Funding: MUSCULAR DYSTROPHY ASSO

Contact Details

Phones:
Business:
(352) 273-8183
Emails:
Business:
ljsznajder@ufl.edu
Addresses:
Business Mailing:
PO BOX 103610
GAINESVILLE FL 326100001
Business Street:
2033 MOWRY RD
GAINESVILLE FL 32610