Donovan J Lott

Donovan J Lott,

RES ASO PROF

Department: HP-PHYSICAL THERAPY
Business Phone: (352) 273-9226
Business Email: djlottpt@phhp.ufl.edu

About Donovan J Lott

Donovan J. Lott, PT, PhD, CSCS, completed his undergraduate degree in Exercise Science at Brigham Young University and his MSPT degree at Washington University School of Medicine. After working in both outpatient and home-health settings as a physical therapist, he returned to Washington University to obtain a PhD in Movement Science with an emphasis in soft tissue mechanics. Donovan came to the University of Florida as a post-doctoral fellow to work with Krista Vandenborne, PhD, PT, in the Muscle Physiology Laboratory. Currently, he is a Research Associate Professor within the Department of Physical Therapy, and his primary teaching responsibilities are in the Basic Skills II and Prosthetics & Orthotics courses for the entry-level DPT students. His research interests include investigating skeletal muscle damage, exercise, and the relationship between muscle pathology and functional mobility in people with neuromuscular disease

Teaching Profile

Courses Taught
2012-2023
PHT6702C Prostetics/Orthotics
2019-2020
PHT6609 Evidence Base Pract 3
2019-2024
PHT6207C Introduction to Exercise Science for Physical Therapists
2011,2019
RSD6905 Individual Work
2010-2011,2013-2017
PHT6608 Evidence Base Pract 2
2009-2015
HSC4970 Public Health and Health Professions Senior Honors Thesis
2014
PHT6935C Seminar
2011
HSC4905 Individual Study
2011
RSD6940 Supervised Teaching
2010
IDH4917 Undergrad Research

Publications

2023
Antisense oligonucleotide targeting DMPK in patients with myotonic dystrophy type 1: a multicentre, randomised, dose-escalation, placebo-controlled, phase 1/2a trial.
The Lancet. Neurology. 22(3):218-228 [DOI] 10.1016/S1474-4422(23)00001-7. [PMID] 36804094.
2022
Characterizing Expiratory Respiratory Muscle Degeneration in Duchenne Muscular Dystrophy Using MRI.
Chest. 161(3):753-763 [DOI] 10.1016/j.chest.2021.08.078. [PMID] 34536384.
2022
Commentaries on Viewpoint: Hoping for the best, prepared for the worst: can we perform remote data collection in sport sciences?
Journal of applied physiology (Bethesda, Md. : 1985). 133(6):1433-1440 [DOI] 10.1152/japplphysiol.00613.2022. [PMID] 36509417.
2022
Development of Contractures in DMD in Relation to MRI-Determined Muscle Quality and Ambulatory Function.
Journal of neuromuscular diseases. 9(2):289-302 [DOI] 10.3233/JND-210731. [PMID] 35124659.
2022
Evaluating Genetic Modifiers of Duchenne Muscular Dystrophy Disease Progression Using Modeling and MRI.
Neurology. 99(21):e2406-e2416 [DOI] 10.1212/WNL.0000000000201163. [PMID] 36240102.
2022
Longitudinal changes in cardiac function in Duchenne muscular dystrophy population as measured by magnetic resonance imaging.
BMC cardiovascular disorders. 22(1) [DOI] 10.1186/s12872-022-02688-5. [PMID] 35681116.
2022
Step Activity Monitoring in Boys with Duchenne Muscular Dystrophy and its Correlation with Magnetic Resonance Measures and Functional Performance.
Journal of neuromuscular diseases. 9(3):423-436 [DOI] 10.3233/JND-210746. [PMID] 35466946.
2021
Safety, feasibility, and efficacy of strengthening exercise in Duchenne muscular dystrophy.
Muscle & nerve. 63(3):320-326 [DOI] 10.1002/mus.27137. [PMID] 33295018.
2021
Walking activity in a large cohort of boys with Duchenne muscular dystrophy.
Muscle & nerve. 63(2):192-198 [DOI] 10.1002/mus.27119. [PMID] 33188573.
2020
Lower Extremity Muscle Involvement in the Intermediate and Bethlem Myopathy Forms of COL6-Related Dystrophy and Duchenne Muscular Dystrophy: A Cross-Sectional Study.
Journal of neuromuscular diseases. 7(4):407-417 [DOI] 10.3233/JND-190457. [PMID] 32538860.
2020
Magnetic Resonance Imaging Studies in Duchenne Muscular Dystrophy: Linking Findings to the Physical Therapy Clinic.
Physical therapy. 100(11):2035-2048 [DOI] 10.1093/ptj/pzaa140. [PMID] 32737968.
2020
Modeling disease trajectory in Duchenne muscular dystrophy.
Neurology. 94(15):e1622-e1633 [DOI] 10.1212/WNL.0000000000009244. [PMID] 32184340.
2020
MR biomarkers predict clinical function in Duchenne muscular dystrophy.
Neurology. 94(9):e897-e909 [DOI] 10.1212/WNL.0000000000009012. [PMID] 32024675.
2020
Upper and Lower Extremities in Duchenne Muscular Dystrophy Evaluated with Quantitative MRI and Proton MR Spectroscopy in a Multicenter Cohort.
Radiology. 295(3):616-625 [DOI] 10.1148/radiol.2020192210. [PMID] 32286193.
2019
Effects of PDE5 inhibition on dystrophic muscle following an acute bout of downhill running and endurance training.
Journal of applied physiology (Bethesda, Md. : 1985). 126(6):1737-1745 [DOI] 10.1152/japplphysiol.00664.2018. [PMID] 30946638.
2019
Imaging respiratory muscle quality and function in Duchenne muscular dystrophy.
Journal of neurology. 266(11):2752-2763 [DOI] 10.1007/s00415-019-09481-z. [PMID] 31350642.
2019
Longitudinal changes in clinical outcome measures in COL6-related dystrophies and LAMA2-related dystrophies.
Neurology. 93(21):e1932-e1943 [DOI] 10.1212/WNL.0000000000008517. [PMID] 31653707.
2019
Lower Extremity Functional Outcome Measures in Duchenne Muscular Dystrophy-A Delphi Survey.
Journal of neuromuscular diseases. 6(1):75-83 [DOI] 10.3233/JND-180337. [PMID] 30562905.
2018
Electrical impedance myography in individuals with collagen 6 and laminin α-2 congenital muscular dystrophy: a cross-sectional and 2-year analysis.
Muscle & nerve. 57(1):54-60 [DOI] 10.1002/mus.25629. [PMID] 28224647.
2018
Leg muscle MRI in identical twin boys with duchenne muscular dystrophy.
Muscle & nerve. [DOI] 10.1002/mus.26081. [PMID] 29365354.
2018
Longitudinal timed function tests in Duchenne muscular dystrophy: ImagingDMD cohort natural history.
Muscle & nerve. 58(5):631-638 [DOI] 10.1002/mus.26161. [PMID] 29742798.
2018
Skeletal muscle magnetic resonance biomarkers correlate with function and sentinel events in Duchenne muscular dystrophy.
PloS one. 13(3) [DOI] 10.1371/journal.pone.0194283. [PMID] 29554116.
2018
Two-Year Longitudinal Changes in Lower Limb Strength and Its Relation to Loss in Function in a Large Cohort of Patients With Duchenne Muscular Dystrophy.
American journal of physical medicine & rehabilitation. 97(10):734-740 [DOI] 10.1097/PHM.0000000000000957. [PMID] 29734234.
2017
Magnetic resonance imaging of the proximal upper extremity musculature in boys with Duchenne muscular dystrophy.
Journal of neurology. 264(1):64-71 [DOI] 10.1007/s00415-016-8311-0. [PMID] 27778157.
2017
Molecular signatures of differential responses to exercise trainings during rehabilitation.
Biomedical genetics and genomics. 2(1) [DOI] 10.15761/BGG.1000127. [PMID] 28845464.
2017
Multi-slice MRI reveals heterogeneity in disease distribution along the length of muscle in Duchenne muscular dystrophy.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology. 36(3):151-162 [PMID] 29774305.
2016
Multicenter prospective longitudinal study of magnetic resonance biomarkers in a large duchenne muscular dystrophy cohort.
Annals of neurology. 79(4):535-47 [DOI] 10.1002/ana.24599. [PMID] 26891991.
2015
Longitudinal Evaluation of Muscle Composition Using Magnetic Resonance in 4 Boys With Duchenne Muscular Dystrophy: Case Series.
Physical therapy. 95(7):978-88 [DOI] 10.2522/ptj.20140234. [PMID] 25592189.
2015
Magnetic Resonance Assessment of Hypertrophic and Pseudo-Hypertrophic Changes in Lower Leg Muscles of Boys with Duchenne Muscular Dystrophy and Their Relationship to Functional Measurements.
PloS one. 10(6) [DOI] 10.1371/journal.pone.0128915. [PMID] 26103164.
2014
Assessment of intramuscular lipid and metabolites of the lower leg using magnetic resonance spectroscopy in boys with Duchenne muscular dystrophy.
Neuromuscular disorders : NMD. 24(7):574-82 [DOI] 10.1016/j.nmd.2014.03.013. [PMID] 24798221.
2014
Chemical shift-based MRI to measure fat fractions in dystrophic skeletal muscle.
Magnetic resonance in medicine. 72(1):8-19 [DOI] 10.1002/mrm.24917. [PMID] 24006208.
2014
Effect of dietary restriction and exercise on lower extremity tissue compartments in obese, older women: a pilot study.
The journals of gerontology. Series A, Biological sciences and medical sciences. 69(1):101-8 [DOI] 10.1093/gerona/gls337. [PMID] 23682155.
2014
Examination of effects of corticosteroids on skeletal muscles of boys with DMD using MRI and MRS.
Neurology. 83(11):974-80 [DOI] 10.1212/WNL.0000000000000775. [PMID] 25098537.
2014
Longitudinal measurements of MRI-T2 in boys with Duchenne muscular dystrophy: effects of age and disease progression.
Neuromuscular disorders : NMD. 24(5):393-401 [DOI] 10.1016/j.nmd.2013.12.012. [PMID] 24491484.
2014
Magnetic resonance imaging and spectroscopy assessment of lower extremity skeletal muscles in boys with Duchenne muscular dystrophy: a multicenter cross sectional study.
PloS one. 9(9) [DOI] 10.1371/journal.pone.0106435. [PMID] 25203313.
2014
Participation in daily life activities and its relationship to strength and functional measures in boys with Duchenne muscular dystrophy.
Disability and rehabilitation. 36(22):1918-23 [DOI] 10.3109/09638288.2014.883444. [PMID] 24499260.
2013
Magnetic Resonance Imaging and Spectroscopy Detect Changes With Age, Corticosteroid Treatment, and Functional Progression in Dmd
Neuromuscular Disorders. 23(9-10) [DOI] 10.1016/j.nmd.2013.06.599.
2013
Mri Measures of Bone in Duchenne Muscular Dystrophy
Neuromuscular Disorders. 23(9-10) [DOI] 10.1016/j.nmd.2013.06.602.
2013
Skeletal muscles of ambulant children with Duchenne muscular dystrophy: validation of multicenter study of evaluation with MR imaging and MR spectroscopy.
Radiology. 269(1):198-207 [DOI] 10.1148/radiol.13121948. [PMID] 23696684.
2013
T₂ mapping provides multiple approaches for the characterization of muscle involvement in neuromuscular diseases: a cross-sectional study of lower leg muscles in 5-15-year-old boys with Duchenne muscular dystrophy.
NMR in biomedicine. 26(3):320-8 [DOI] 10.1002/nbm.2851. [PMID] 23044995.
2012
Age-related differences in lower extremity tissue compartments and associations with physical function in older adults.
Experimental gerontology. 47(1):38-44 [DOI] 10.1016/j.exger.2011.10.001. [PMID] 22015325.
2012
MRI/MRS evaluation of a female carrier of Duchenne muscular dystrophy.
Neuromuscular disorders : NMD. 22 Suppl 2(Suppl 2):S111-21 [DOI] 10.1016/j.nmd.2012.05.013. [PMID] 22980762.
2012
Participation and quality of life in children with Duchenne muscular dystrophy using the International Classification of Functioning, Disability, and Health.
Health and quality of life outcomes. 10 [DOI] 10.1186/1477-7525-10-43. [PMID] 22545870.
2012
Relationships of thigh muscle contractile and non-contractile tissue with function, strength, and age in boys with Duchenne muscular dystrophy.
Neuromuscular disorders : NMD. 22(1):16-25 [DOI] 10.1016/j.nmd.2011.06.750. [PMID] 21807516.
2012
Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study.
PloS one. 7(2) [DOI] 10.1371/journal.pone.0032829. [PMID] 22389725.
2011
Design of a Multi-Center Study To Examine Skeletal Muscles of Children With Duchenne Muscular Dystrophy Using Mri/Mrs
Neuromuscular Disorders. 21(9-10):653-654 [DOI] 10.1016/j.nmd.2011.06.801.
2011
Magnitude of spinal muscle damage is not statistically associated with exercise-induced low back pain intensity.
The spine journal : official journal of the North American Spine Society. 11(12):1135-42 [DOI] 10.1016/j.spinee.2011.11.005. [PMID] 22208857.
2010
Age-related differences in lower-limb muscle cross-sectional area and torque production in boys with Duchenne muscular dystrophy.
Archives of physical medicine and rehabilitation. 91(7):1051-8 [DOI] 10.1016/j.apmr.2010.03.024. [PMID] 20599043.
2010
Daily Step Count, Gait Parameters, Strength, and Function in Children With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise. 42
2010
Distribution of T2 in the Soleus Muscle of Children With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise. 42
2010
Muscle Pathology and Functional Ability in Children With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise. 42
2010
Nnls Analyses of Skeletal Muscle T2 in Children With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise. 42
2010
Skeletal Muscle Contractile and Non-Contractile Components in Boys With Duchenne Muscular Dystrophy By Mri
Medicine and Science in Sports and Exercise. 42
2008
Multi-plug insole design to reduce peak plantar pressure on the diabetic foot during walking.
Medical & biological engineering & computing. 46(4):363-71 [DOI] 10.1007/s11517-008-0311-5. [PMID] 18266017.
2008
Muscle Strength and Functional Status in Boys With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise. 40(5) [DOI] 10.1249/01.mss.0000323019.33764.4c.
2007
Effect of footwear and orthotic devices on stress reduction and soft tissue strain of the neuropathic foot.
Clinical biomechanics (Bristol, Avon). 22(3):352-9 [PMID] 17182156.
2007
Effect of metatarsal pad placement on plantar pressure in people with diabetes mellitus and peripheral neuropathy.
Foot & ankle international. 28(1):84-8 [PMID] 17257544.
2007
Effect of peak pressure and pressure gradient on subsurface shear stresses in the neuropathic foot.
Journal of biomechanics. 40(4):883-90 [PMID] 16677657.
2006
Efficacy and mechanism of orthotic devices to unload metatarsal heads in people with diabetes and a history of plantar ulcers.
Physical therapy. 86(6):833-42 [PMID] 16737409.
2006
Numerical simulation of the plantar pressure distribution in the diabetic foot during the push-off stance.
Medical & biological engineering & computing. 44(8):653-63 [PMID] 16937207.
2005
“Pressure gradient” as an indicator of plantar skin injury.
Diabetes care. 28(12):2908-12 [PMID] 16306553.
2005
Relationship between changes in activity and plantar ulcer recurrence in a patient with diabetes mellitus.
Physical therapy. 85(6):579-88 [PMID] 15921478.
2004
Impact of achilles tendon lengthening on functional limitations and perceived disability in people with a neuropathic plantar ulcer.
Diabetes care. 27(7):1559-64 [PMID] 15220228.

Grants

Sep 2022 ACTIVE
FDA – Establishing Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type-1 (Renewal)
Role: Other
Funding: VA COMMONWEALTH UNIV via US FOOD AND DRUG ADMN
Sep 2022 ACTIVE
Muscular Dystrophy Clinical Trial Research Network
Role: Other
Funding: UNIV OF KANSAS MEDICAL CTR via MUSCULAR DYSTROPHY ASSO
Sep 2021 ACTIVE
Measuring cardiopulmonary responses to the 6MWT and peak effort exercise in DMD
Role: Co-Investigator
Funding: MUSCULAR DYSTROPHY ASSO
Dec 2020 ACTIVE
Motor Outcomes to Validate Evaluations in FSHD (MOVE FSHD)
Role: Other
Funding: UNIV OF KANSAS MEDICAL CTR via FACIOSCAPULOHUMERAL SOCIETY
Sep 2020 ACTIVE
Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Aug 2020 ACTIVE
Development of MRI, Alternative Splicing, and Functional Abilities as Biomarkers in Myotonic Dystrophy Type 1
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Jul 2019 ACTIVE
Impact and Interplay of Corticosteroid Regimen and Exercise Training on DMD Muscle Function
Role: Co-Investigator
Funding: US ARMY MED RES ACQUISITION
Jul 2019 – Jun 2022
Myotonic Dystrophy Clinical Research Network
Role: Project Manager
Funding: UNIV OF ROCHESTER via MUSCULAR DYSTROPHY ASSO
Nov 2018 – Aug 2022
Establishing Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type-1 (END-DM1) "Study"
Role: Other
Funding: VA COMMONWEALTH UNIV via US FOOD AND DRUG ADMN
Jun 2016 – Aug 2018
Development of Magnetic Resonance Imaging as an Endpoint in Myotonic Dystrophy Type 1
Role: Principal Investigator
Funding: WYCK FOUNDATION via MYOTONIC DYSTROPHY FOU
Sep 2015 – Sep 2020
Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Aug 2015 – Jul 2021
Failed Regeneration in the Muscular Dystrophies: Inflammation, Fibrosis and Fat
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Nov 2014 – Nov 2017
A Phase 1/2a Blinded, Placebo-Controlled Study to Assess the Safety, Tolerability, and Dose-range Finding of Multiple Ascending Doses of ISIS 598769 Administered Subcutaneously to Adult Patients with Myotonic Dystrophy Type 1
Role: Project Manager
Funding: INC RESEARCH INC
Sep 2014 – Jun 2018
Development of a Strength Training Protocol in Duchenne Muscular Dystrophy
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Sep 2011 – Mar 2016
Florida Trauma Rehabilitation Center for Returning Military Personnel
Role: Project Manager
Funding: US DEPT OF DEFENSE

Education

PhD: Movement Science (Biomechanics emphasis)
2007 · Washington University in St. Louis
MS: Physical Therapy
1998 · Washington University School of Medicine
BS: Exercise Science
1996 · Brigham Young University

Contact Details

Phones:
Business:
(352) 273-9226
Emails:
Addresses:
Business Mailing:
PO BOX 100154
DEPARTMENT OF PHYSICAL THERAPY
GAINESVILLE FL 326100154