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UF Health University of Florida
Center for NeuroGenetics College of Medicine
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Shu Guo

Shu Guo

AST SCTST

Department: Molecular Genetics & Microbiology
Business Phone: (352) 273-5188
Business Email: s.guo@ufl.edu

On This Page

Publications

Academic Articles

  1. Repeat-associated non-AUG translation as a common mechanism for the polyGln ataxias.

    Journal
    Cell reports.
    Volume/Issue
    45(1)
    [DOI]
    10.1016/j.celrep.2025.116741.
    [PMID]
    41422503.
    3 citations PubMed Publisher’s Site

  2. PolyGR-containing aggregates link with pathology and clinical features of Alzheimer’s disease.

    Journal
    Acta neuropathologica.
    Volume/Issue
    150(1)
    [DOI]
    10.1007/s00401-025-02954-8.
    [PMID]
    41204969.
    1 citation PubMed Publisher’s Site

  3. CASP8 intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer’s disease risk.

    Journal
    Proceedings of the National Academy of Sciences of the United States of America.
    Volume/Issue
    122(7)
    [DOI]
    10.1073/pnas.2416885122.
    [PMID]
    39937857.
    5 citations PubMed Publisher’s Site

  4. RAN proteins in neurodegenerative disease: Repeating themes and unifying therapeutic strategies.

    Journal
    Current opinion in neurobiology.
    Volume/Issue
    72:160-170
    [DOI]
    10.1016/j.conb.2021.11.001.
    [PMID]
    34953315.
    18 citations PubMed Publisher’s Site

  5. Survival and Motor Phenotypes in FVB C9-500 ALS/FTD BAC Transgenic Mice Reproduced by Multiple Labs.

    Journal
    Neuron.
    Volume/Issue
    108(4):784-796.e3
    [DOI]
    10.1016/j.neuron.2020.09.009.
    [PMID]
    33022226.
    36 citations PubMed Publisher’s Site

  6. Metformin inhibits RAN translation through PKR pathway and mitigates disease in C9orf72 ALS/FTD mice.

    Journal
    Proceedings of the National Academy of Sciences of the United States of America.
    Volume/Issue
    117(31):18591-18599
    [DOI]
    10.1073/pnas.2005748117.
    [PMID]
    32690681.
    117 citations PubMed Publisher’s Site

  7. Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model.

    Journal
    Neuron.
    Volume/Issue
    105(4):645-662.e11
    [DOI]
    10.1016/j.neuron.2019.11.007.
    [PMID]
    31831332.
    84 citations PubMed Publisher’s Site

Contact Details

Phones:
Business:
(352) 273-5188
Emails:
Business:
s.guo@ufl.edu
Addresses:
Business Mailing:
PO Box 103610
 GAINESVILLE FL 326103010
Business Street:
2033 MOWRY RD
 GAINESVILLE FL 32610