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David Borchelt

Professor of Neuroscience
Director, SantaFe Health Alzheimer’s Disease Research Center
Investigator, McKnight Brain Institute & CTRND

Phone: (352) 273-9664
Email: borchelt@mbi.ufl.edu

 Center for Translational Research in Neurodegenerative Disease
Biomedical Sciences Building RM J491
Gainesville, FL 32610

 

Research Focus and Aims
Over the past several years there has been tremendous progress in identifying the gene products that mediate a number of neurodegenerative disorders, including familial Alzheimer’s disease, familial amyotrophic lateral sclerosis, and Huntington’s disease. These disorders are all progressive, fatal disorders that result from the dysfunction and death of specific populations of nerve cells. In all of these disorders, a change in the amino acid sequence of specific proteins initiates a cascade of events that lead to disease. A common feature of these disorders is the accumulation of misfolded proteins or peptides in regions of the CNS affected by each disease. My laboratory is committed to investigations designed to elucidate the molecular processes by which specific mutant proteins cause disease. This work involves the use of transgenic mouse models, knockout mice, and cell culture systems to examine the effect of mutations on the function and biology of the mutated proteins. Collectively, these approaches provide insight into the molecular mechanisms of disease and have the potential to identify new therapeutic strategies for these disorders.

For Complete Listing of Publications extracted from PubMed
Click to view publication list