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Dr. David A. Ostrov

David A. Ostrov, PhD
Associate Professor

Office: (352) 273-8166
Lab: (352) 273-8174
Fax: (352) 273-8285

Dept. of Pathology, Immunology and Laboratory Medicine
University of Florida, College of Medicine
P.O. Box 103633
Gainesville, FL 32610-3633

Office Location and Express Mail address:
Dept. of Pathology, Immunology and Laboratory Medicine
University of Florida College of Medicine
Room 494, Cancer/Genetics Research Complex
2033 Mowry Road
Gainesville, FL 32611

Program Assistant:
Dana Hallstrom (352) 273-8288

Office: Cancer/Genetics Research Complex Room 494
Lab: Cancer/Genetics Research Complex Room 475
Structure-based Drug Design Lab: Cancer/Genetics Research Complex Room 265
Lab web page: Ostrov Lab

Currently Involved In:

Our group utilizes methods in structure-based drug design to discover and develop novel therapies for preventing and treating human diseases. The laboratory has experience employing a diverse set of biophysical techniques including X-ray crystallography to answer questions regarding immune recognition. Our team focuses on developing novel therapeutic approaches to treat esophageal cancer, breast cancer, drug resistant childhood leukemia, colon cancer, lung cancer, prostate cancer, lymphoma, Type I diabetes, Graft Versus Host Disease, Rheumatoid Arthritis, Autism Spectrum Disorders and drug resistant pathogens including HIV. Our laboratory developed a unique rapid and economical method to combine in silico high-throughput screening with functional structure-activity-relationship testing in vitro and in vivo.

 

Select Publications:

 

Find out more about the Ostrov lab:

General webpage:
http://my.ufscc.ufl.edu/memarea/sbdd/index.html

Cancer:
http://www.research.ufl.edu/publications/explore/past/summer2008/story_3/index.html

Hypertension/heart disease:
http://news.ufl.edu/2008/05/01/heart-effects/
http://news.ufl.edu/2008/05/01/ace/
http://www.gainesville.com/article/20080623/NEWS/806230306
http://www.genengnews.com/genCasts.aspx?id=213
http://www.drugdiscoverynews.com/index.php?newsarticle=2215

Immune system:
http://news.ufl.edu/2006/10/03/immune/
http://news.health.ufl.edu/2006/6580/colleges/college-of-medicine/tiny-tampa-bay-fish-key-to-evolution-of-immune-system/
http://www.underwatertimes.com/news.php?article_id=83410560791

Drug Discovery:
http://my.ufscc.ufl.edu/memarea/sbdd/index.htm